Sanofi and GlaxoSmithKline Snag Biggest Coronavirus Vaccine Deal Yet

The French drug maker Sanofi said on Friday that it had secured an agreement of up to $2.1 billion to supply the U.S. federal government with 100 million doses of its experimental coronavirus vaccine, the largest such deal announced to date.

The arrangement brings the Trump administration’s investment in coronavirus vaccine projects to more than $8 billion. This sprawling, multiagency effort, known as Operation Warp Speed, is placing bets on multiple vaccines and is paying companies to manufacture millions of doses before clinical trials have been completed.

“The global need for a vaccine to help prevent Covid-19 is massive, and no single vaccine or company will be able to meet the global demand alone,” Thomas Triomphe, executive vice president and global head of Sanofi Pasteur, the company’s vaccine division, said in a statement.

Also on Friday, the European Union said it was working on a deal with Sanofi to buy up to 300 million doses of potential vaccines to distribute to citizens in its 27 member countries. The announcements came two days after a deal with the British government to supply up to 60 million doses of the vaccine. Financial details of those deals were not disclosed.

Under the U.S. deal, Sanofi and its partner, the British pharmaceutical company GlaxoSmithKline, will receive federal funding to pay for clinical trials as well as for manufacturing the vaccine. Sanofi said the deal also includes an option for the company to supply an additional 500 million doses. The company expects to begin clinical trials to test for safety in September, followed by late-stage efficacy trials before the end of this year. Sanofi said it could apply for regulatory approval in the first half of next year.

If the vaccine is successful, it would be made available to Americans at no cost, other than what providers charge to administer it, the federal government said in a statement.

The head of Operation Warp Speed, Moncef Slaoui, is a former GSK executive who

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Sanofi’s coronavirus vaccine relies on a protein-based technology that the company already uses to produce an influenza vaccine. It is similar to a technique used by another company, Novavax, that will receive up to $1.6 billion from the Defense Department and the Department of Health and Human Services to develop its experimental vaccine. GSK is supplying the Sanofi vaccine with an adjuvant, an ingredient used in many vaccines that boosts the immune response.

Sanofi is also developing a separate vaccine in partnership with Translate Bio that uses so-called messenger RNA to provoke an immune response in the body. That vaccine is expected to enter clinical trials in the fall.

As a French company, Sanofi has had to carefully navigate the geopolitics of vaccine development. In May, the company’s chief executive, Paul Hudson, faced backlash after he said the United States would get the largest number of doses because they were investing the most.

The remarks caused the company to backpedal, explaining that “We have always been committed in these unprecedented circumstances to make our vaccine accessible to everyone.”

Matina Stevis-Gridneff contributed reporting from Brussels.

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Author: Katie Thomas
August 1, 2020